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The Political Landscape is a weekly podcast where we discuss the news of the day with leading experts and analysts.
A series of ongoing protests at U.S. embassies and consulates have swept across several Middle Eastern countries the past few weeks. Many of these are countries that experienced changes in leadership during the Arab Spring: Egypt, Libya, Yemen, and Tunisia.
Ben Gilbert is a news editor for Al-Monitor.com, a new website devoted to news from and about the Middle East. Gilbert is currently working out of Beirut, Lebanon, and has been living in the Middle East for seven years. He was in Libya during the Arab Spring, and is now witnessing the Mid-East protests first-hand in Lebannon.
When we spoke with Gilbert, he had had to leave his office early because of protests in downtown Beirut. The phone connection was lost a few times during the conversation, so our apologies for the changing sound quality.
The ongoing protests across the Middle East have spurred a larger discussion over how America should handle these emerging democratic governments in the region.?National Journal senior correspondent James Kitfield has written on this topic several times in the last few weeks. Kitfield has covered national security and foreign policy for over two decades, winning awards for his first-hand coverage of the war in Afghanistan and the surge in Iraq. When we spoke with Kitfield, he said it was imperative that U.S. be on the right side of history in the Middle East, even if that means accepting an unstable landscape for the time being.
Check out last week's episode on the state of Iran's nuclear program.
Check out all past episodes of the Political Landscape.
Source: http://news.yahoo.com/mid-east-protests-twitter-confrontations-democracy-135710527--politics.html
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Name:Aly Lyndel
Age:16
Physical Characteristics: Black hair, grey eyes, Slim and tall. Black Fox ears and tail
Personality: Shy, sweet, calm,soft-spoken
The bell rang and everybody left class, Aly and her cat friend Carla rushed out of class with the crowd, Carla laughed "Oh man, that was hilarious, can you believe Mrs. Burgman is so deaf she didn't hear anyone yell 'penis'?" We both laughed hysterically, just then her boyfriend Brad came up "Oh see you later, Aly!" She walked off cuddling Brad, her tail swishing happily. "B-bye" I said, sighing as I walked home alone.
Carla was a good friend and all, but she has tons of other friends, not to mention her boyfriend. It seemed everyone had tons of friends, or at least just their boyfriend. She just had Carla, but she didn't just have her, and as for boyfriends, she probably couldn't talk to a boy to save her life. The most awkward thing however, was Carly always talked about losing her virginity to Brad and sex with Brad, to which she had no idea at all about.
That friday night after school, she took a walk to a field of grass, it was far from the houses and away from just about everyone. She sat in the center of the field and laid on her back, she watched the stars twinkle, a scintillating blanked of beauty, led by the glowing disc of the moon. She sighed, for once she wished there was someone that she would be just as important to as they were to her.
Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/H0j1WVPzJIE/viewtopic.php
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AUSTIN, Texas, Sept. 27, 2012 /PRNewswire-iReach/ -- AFP announces it's new subsidiary AFP China. Headquartered in Shanghai, China, AFP China will work in conjunction with AFP Austin to design, engineer, and source environmentally sustainable packaging solutions for Multi-National businesses with manufacturing in China and businesses serving the local China market. The AFP China team will also leverage its' supply chain management expertise to improve efficiency and inventory management within the China packaging supply chain.? AFP will extend the reach of its' manufacturing technology and processes by collaborating with leading Chinese packaging suppliers to improve efficiency and quality through innovation and automation.
"Our new business in China, not only extends our capability to supply our existing customer base of the world's leading high technology companies, it opens new opportunities to supply the world's largest packaging market with our innovative packaging designs and manufacturing technology while leveraging our supplier relationships to globalize environmentally sustainable, cost reducing, packaging solutions," stated Tim O'Hearn, CEO of AFP, Inc.
"Having engineering teams, on both sides of the world will enable collaborative round the clock engineering and design capabilities along with the ability to deliver packaging solutions where our customers need them and when they need them," said Jodie Zhang, General Manager of AFP China.
AFP, Inc., headquartered in Austin, Texas and Shanghai, China with five manufacturing locations serving the United States and Mexico, has provided leading high technology companies like Acer, Dell, Flextronics, HP and IBM with innovative and cost reducing engineered packaging solutions since 1978. For more information about AFP, Inc. contact Rick Lange on 512-251-6300 or visit www.a-f-p.com.
Media Contact: Rick Lange AFP Inc., +1(512)251-6300, RIckLange@a-f-p.com
News distributed by PR Newswire iReach: https://ireach.prnewswire.com
SOURCE AFP Inc.
Source: http://www.businessreviewaustralia.com/press_releases/afp-expands-operations-into-china
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ScienceDaily (Sep. 26, 2012) ? The parasitic mite Varroa destructor is a major contributor to the recent mysterious death of honey bee (Apis mellifera) colonies. New research published in BioMed Central's open access journal Genome Biology finds that specific proteins, released by damaged larvae and in the antennae of adult honey bees, can drive hygienic behavior of the adults and promote the removal of infected larvae from the hive.
V. destructor sucks the blood (hemolymph) of larval and adult bees leaving them weakened and reducing the ability of their immune systems to fight off infections. Not that honey bees have strong immune systems in the first place since they have fewer immunity genes than solitary insects such as flies and moths. These tiny mites can also spread viral disease between hosts. This double onslaught is thought to be a significant contributor to Colony Collapse Disorder (CCD).
But all is not lost -- honey bees have evolved a way to fight back: hygienic behavior where diseased or parasitized larvae are removed from their brood cells, and Varroa-sensitive hygienic behavior which they use to reduce the number of reproductive mites on remaining larvae.
To find exactly how bees respond to hive infections, researchers from Canada looked at the natural behavioral of bees in the presence of damaged larvae and compared this to protein differences in the larvae and adults. After scanning 1200 proteins the team found that several proteins, including LOC552009 (of unknown function but similar to ApoO), found in the antennae of adults were associated with both uncapping brood cells and the removal of larvae. Other proteins were involved in olfaction or in signal transduction, probably helping the adults find infected larvae amongst a brood.
In damaged larvae, transglutaminase, a protein involved in blood clotting, was upregulated, which appeared to be a key component in regulating the adult's behavior. Other proteins indicated adaptations to help fight infection, including chitin biosynthesis and immune responses.
Dr Leonard Foster from CHIBI at the University of British Columbia, who led this research said, "Bee keepers have previously focused on selecting bees with traits such as enhanced honey production, gentleness and winter survival. We have found a set of proteins which could be used to select colonies on their ability to resist Varroa mite infestation and can be used to find individuals with increased hygienic behavior. Given the increasing resistance of Varroa to available drugs this would provide a natural way of ensuring honey farming and potentially survival of the species."
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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/t7G0qfiJJY0/120927205308.htm
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Satisfaction with homeowners insurance companies increases as more policies are bundled, according to a study released Thursday.
The 12th annual J.D. Power and Associates 2012 U.S. National Homeowners Insurance Study measures customer satisfaction based on five factors: billing and payment, claims, interaction, policy offerings and price. This year?s study showed the highest satisfaction level in the study?s history, improving 16 points from last year.
Using a 1,000-point scale, the study shows an improvement of 19 points among customers who bundle auto and home insurance policies with the same insurer. Customer satisfaction among those who have their auto policy with a separate insurer rose 10 points.
Bundling also increases intent to renew policies, the study noted. About 28% of those who have homeowners insurance only said they ?definitely will? renew, while 46% of those who bundle said they ?definitely will.? And when four or more policies are bundled, that increases to 66%.
The overall retention rate is 89%, but among customers who bundle that rises to 95%. The report shows the benefit of bundling rises when an auto policy is added more than adding an umbrella policy. And while about 25% of customers have umbrella policies, which are more prevalent among those with high incomes, those policies have a high rate of bundling. Adding life insurance, however, provides no increase in stated retention, according to the report.
Overall, satisfaction in all five categories increased this year, with the greatest gains in policy offerings and billing and payment factors. The report notes that the competitiveness of discounts and the variety of coverage options are key differentiators among those who bundle insurance.
Factors that influence product density include multi-product discounts ? the single largest driver with more than half the influence. Customer service also is a large driver, as is age, with younger generations bundling more, and having a local agent.
Jeremy Bowler, senior director of J.D. Power?s insurance practice, said insurance companies have an opportunity to create loyal customers by bundling policies. Once bundled, customers are more likely to keep the policies bundled and to add more products in the future, he added.
The study showed that State Farm Insurance has the highest rate of bundling at 80 %, while Amica Mutual ranked highest in customer satisfaction for the 11th year.
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Source: http://ifawebnews.com/2012/09/27/customer-satisfaction-with-homeowners-insurance-hits-record-high/
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If you've been following the surge of AirPlay speakers that started hitting the market in 2011, you've likely feasted your eyes on the spendy wool-clad systems by Libratone. While its larger Live and Lounge units have primarily been purposed for households, its new Zipp speaker is the being touted as the "first and only" portable AirPlay speaker. Make no mistake, unlike B&O Play's portable AirPlay-equipped Beolit 12 ($800), the Zipp's loaded with Libratone's proprietary PlayDirect protocol, meaning it doesn't require a separate wireless network / router for iDevices to connect to it over the air. The Zipp moniker is a play on the swappable wool grill which cozies around its vertically-standing tubular enclosures. Weighing four pounds and measuring in at 10.2 inches high by 4.8 inches in diameter, this "portable" unit is a good bit larger than the Blutooth-equipped Jawbone Big Jambox placed sideways, but it'll certainly fit in a backpack -- hey, it does have a leather carrying strap. Thankfully, that weight is partially due to its internal rechargeable battery, which should last up to eight hours.
As far as the speakers go, you'll find a duo of 1-inch ribbon tweeters facing the sides for the left and right channels, along with a 4-inch up-firing woofer. The rig also features Libratone's signature FullRoom design, which forces a 360-degree dispersion of the sound by way of deflectors in front of the tweeters. Beyond that, it'll naturally work with Libratone's existing iPhone app, allowing you to change the DSP on the fly for optimal output regardless of its placement in a room. The Zipp will hit Apple Stores later this October wrapped with a single red or grey zippered grill for $399, while other retailers will carry the $449 Classic Color and Funky Color editions, which each come with a trio of those wool grills (black, blue and red for the Classic, and black, pink and yellow for the Funky). Past that, a single grill by itself will cost you a relatively expensive $49 directly from Libratone. In the meantime, join us past the break for more details about the unit itself and PlayDirect, our initial impressions and a hands-on video overview.
Filed under: Portable Audio/Video
Libratone intros Zipp portable AirPlay speaker with DirectPlay, expectedly wrapped in wool (update) originally appeared on Engadget on Wed, 26 Sep 2012 18:00:00 EDT. Please see our terms for use of feeds.
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FORT WAYNE, Ind. (WANE) - State leaders are hoping a new billboard will surprise motorists around Fort Wayne.? The billboard says "every 25 minutes someone dies from a prescription drug overdoes in the U.S."? The billboard is expected to be up by the end of September.
Indiana Attorney General Greg Zoeller announced the billboard this week.? According to his office, the billboard will be displayed along the side of U.S. 24, east of S.R. 930.? The billboard will be displayed in other Indiana cities across the state as well.
"Prescription drug overdoses and the non-prescription use of medication is an epidemic that continues o have a stronghold in our communities, Zoeller, who heads a newly created Prescription Drug Abuse Task Force, said in a press release this week.? "It's critical everyone work together to break away from this trend.? I believe any solutions will require a comprehensive approach that includes education, training, treatment, tracking and enforcement."
The task force is made up of state leaders, along with police and health officials.? It's designed to create rules and regulations to stop prescription drug abuse.
"Any time you can get out there and that type of stuff to the public, make them more aware of the problem, that's a great thing," Steve Ribolla, a group supervisor at the Drug Enforcement Administration's Fort Wayne office, said about the idea of using a billboard to get the message out.? "It's very similar to the meth ads that are out their on television now."
Zoeller told NewsChannel 15 the billboard gives Hoosiers a wake-up call.
According to Dr. Deb McMahan, the director of the Fort Wayne-Allen County Department of Health, there were 29 deaths caused by a drug overdose in Allen County during 2011.? She added 25 of those were caused by multiple drugs or prescription drugs.
McMahan explained the problem began in the 1990s.? During that time, patients were complaining of pain, and the medical community was being asked to help patients cope with it.? From there, doctors began prescribing more pain medications.
"The number of prescriptions being written for pain medications is just really increasing," McMahan, who plans to be a part of the task force, said.? "As that happens, so is the abuse."
As the task force looks at ways to reduce abuse and misuse, McMahan shared her ideas on how to curb the problem.
"We need to develop a community standard for prescribing medications," she said.? "Including the types of meds we prescribe, and the number of pills you're given."
Zoeller also said some patients are given too much medication.
"Over prescribing comes from the regular family physician," he said.? Zoeller recognized some patients have an overwhelming amount of pain, but in some cases, patients do not need as much pain relief.? "You get a tooth ache, and they prescribe 50 oxycodone.? They over prescribe what ends up being in your medicine cabinet, so the first thing we have to do is ratchet down."
That leftover medicine is what law enforcement looks for.
The announcement of the new billboards comes on the heels of "Wake Up to Medicine Abuse Week," which began Sunday and runs through Saturday.? This national effort encourages parents to take action by, first, educating their children about the dangers of abusing prescription medicines, and second, safely disposing of unused medications.
Hoosiers can safely turn-in unwanted medication Saturday during National Prescription Drug Take-Back Day from 10 a.m. to 2 p.m. at the Indiana State Police post in Fort Wayne."
A similar event took place in April.? On that day, 276 tons of medication.? During the last four nationwide events, a 775 tons were collected and destroyed.
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In the United States, the role of fathers has changed over the years. Dads are much more involved in their children?s lives than their fathers were and many even stay at home to care for the kids while their wives work. Today?s dads are as likely to change a diaper as they are to change the oil in a car.
When you consider the roles of fathers in other countries, you gain an appreciation of how dads interact within the family unit. You also begin to see how lingering stereotypes continue to plague fathers around the world.
The following video, produced by the International Museum of Women, explores fatherhood from a global perspective and sheds light on how dads are perceived worldwide.
Share your thoughts on this video and on fatherhood in general in the comments section below.
Stay Strong,
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Source: http://www.mochadad.com/2012/09/moms-around-the-world-share-their-perceptions-on-fatherhood/
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I?m a pretty health conscience guy who plays tennis three times a week, watches what he eats, and goes on frequent hikes and bike rides around the neighborhood. That said, I?ve definitely been overweight before, and I came close again on my recent trip to Europe.
The reasons why I want to stay relatively fit are as follows:
* I don?t want to die before my time. Although we don?t know when we will die, we can at least try and reduce our chances of an early death by eating right and exercising regularly.
* I don?t want to burden my family with unnecessary health complications. Being a burden to loved ones is a terrible, terrible thing. I would hate to see my wife, kids, or relatives have to constantly check in on me because I?ve received brain damage from a stroke, or can no longer go to the bathroom on my own due to some manly cancer.
* I don?t want to financially burden my fellow Americans who will have to subsidize my medical costs thanks to universal health care. As honorable citizens, we should try to give back more to our country more than we receive. This is the best way to ensure the health of our nation?s future.
* I don?t want to let my US Tennis Association teammates down when it?s time to battle other teams. We all train very hard in the off season so that come game time, we?re ready to compete. Being physically fit is standard, but can also be a huge edge as we battle less in shape competitors. Once we are fit, we can then concentrate on our skills and mental fitness which are crucial to winning matches.
* I?m frugal and don?t want to spend too much on new clothes. During the first year of college and the first year of work I had to buy new shirts and pants because I gained about 15 pounds. I?m not big into clothing in the first place, but when you?ve got to buy a three new suits of different colors, things add up! Dress shirts and jeans are easily $50-$200 each and higher. Imagine being able to fit in your jeans from 10-15 years ago, how much money you can save!
* I don?t want to ignore the plight of others. I grew up in several third world countries and I?ve witnessed immense poverty. When I know there are millions of people starving around the world, there?s no way I can overeat and not remember. America is a country of abundance and it?s easy to consume more than normal. We just have to remind ourselves how lucky we are, as we?re not even being asked to help others, only ourselves.
* I want to feel good. When I was heavier, I didn?t have as much energy and I didn?t feel as good about myself. I?d look at new pictures and come away shocked because they were so different from how I used to look. When you feel good, you look good. And when you look good, you have more confidence to succeed.
Despite all these reasons, I still find it very tough to stay in ideal weight of 152-163 pounds for someone 5 feet 10 inches tall. 152 pounds sounds ridiculously light, but hey, that?s what the doctors and researchers say is ideal weight for a medium bodied person my height, so who am I to make excuses?
The problem is, when I see a batch of lemon meringue mini pastries, I cannot help but eat six of them at a time! When there is all you can eat BBQ ribs, the same thing happens. Tell me I?m not the only one!
My friends and I walked on average four hours a day for 10 out of the 17 days we were in Europe. Our ship would dock by 8am, and we?d go from around 8:30am all the way to 5pm exploring every single city. That?s 8.5 hours off the boat at each port, with half the time walking.
Given it takes 16-20 minutes on average to walk a mile, we walked 12-15 miles a day for 10 days. We walked another three miles a day for the other seven days the rest of the time. ?If we add up everything, we averaged about 8-9 miles of walking a day for 17 days!
During long lines at the Van Gogh Museum in Amsterdam, or during down time at the gardens of Catherine?s Palace in St. Petersburg, we?d try and get at least 30 pushups and 50 sit-ups in as well. The reason being we knew that a dinner buffet or scrumptious meal high in butter and joy awaited us once we returned to the ship!
Furthermore, we?d all hit the swimming pull and gym at least twice a week to try and get at least a 30 minute sweat in.
* Breakfast: Omellette, bacon, sausage, a couple mini pastries, Norweigan fish, and OJ.
* Lunch: Local meal on land if at port, or another buffet meal on board while at sea. We?d generally eat a salad, piece of flank steak, shrimp cocktail and some juicer
* Dinner: Rib-eye, filet mignon, prime rib, rack of lamb, beef wellington, lobster, sushi, sashimi, chef salads, creme brulee, hot fudge sundae, apple cobbler, cheese platters and much, much more.
* Evening snack and beverages: The restaurants would open up at 10pm again until midnight where you could eat the same food that they served during lunch. Every other night there would be some type of dessert extravaganza, and of course, if you are like me, you enjoy the cocktail at a ship bar or while you?re playing poker until 2am!
Despite the availability of food, I did my best to eat until slightly full and not pig out until I felt sick. I went for quality food items instead of quantity. But, when you are eating such treats every single day, it is hard not to put on some weight.
I ate 10 of them in two days
Now that you know my daily exercise routine and meal itinerary, guess how much weight I gained in just seventeen days? Remember, I walked 8-9 miles on average, put in the occasional work out, and tried to eat in moderation.
I went from 160 pounds to 170 pounds in two and a half weeks! To compare apples to apples, nine pounds is a whopping % i6ncrease in body weight in such a short time.
I knew I was gaining weight because my jeans felt tighter each day that passed by, but I didn?t realize how much I gained until I got back to San Francisco. I was shocked after spending the first 3-4 months of the year trying to lose 8-10 pounds, I had gained it all back in just a matter of weeks.
The ideal body weight of 152-163 for someone 5? 10? pisses me off. As I mentioned in the beginning of the post, I have many reasons why I want to stay in shape, and I?m assuming that many of you guys have similar reasoning.
As a result, I?ve decided to join WeightTraining.com to exercise more, track my progress, and have some fun competing with other people online who want to get in shape and stay in shape! WeightTraining.com offers free workout logging, an exercise database with 2,000+ exercises, various fitness challenges, and the ultimate motivation in fitness battles.
My exercise routine will be as follows:
* Three sets of 20 push-ups for a total of 60 a day
* Three sets of 50 sit-ups for a total of 150 a day
* Five hours of tennis a week
* One hour of biking a week
* One hour of hiking a week
The goal is to burn about 500 calories a day beyond normal activity.
As for food, I plan to go back to my normal eating habits of fruit and barley green in the morning, a regular lunch under 700 calories, and dinner under 1,000 calories for a total of 2,200 calories or less. If I can consume a net 1,700 calories a day, I?m pretty sure that within a couple months I?ll be able to get back down to 160 lbs and hopefully down to 155 lbs, the weight I was back in high school.
You can find me on WeightTraining.com with the account FinSamurai. WeightTraining.com motivates users to workout by rewarding points for logged workouts. This workout summary will give you a better idea on how exercises are accounted for within a workout (Note: This workout summary is from Yakezie Member, and WeightTraining Founder Joel Ohman?s most recent workout). We plan to do a weekly challenge based on how much we exercise and tally up our points. It?s a fun way to keep accountable and lose weight and stay in shape together.
Join the fitness battle here! Battle starts October 1st at midnight! Who?s in?
Regards,
Sam
Source: http://www.financialsamurai.com/2012/09/25/walking-and-light-exercise-does-nothing-for-weight-loss/
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News 12 at 11 / Friday, September 21, 2012
EVANS, Ga.-- The disease already affects more than 5,000,000 Americans, but as the baby boomers are getting older, that number is about to rise.
"We need to get it as a country, because if we don't, our healthcare system is probably not set up to care for all the things that are going to happen to the baby boomers that are going to age," said Alzheimer's Association Development Director Dee Dee Kurilla.
They call it the long goodbye. Alzheimer's is the heartless disease that robs you of your mind, and millions of Americans are suffering through it.
"It's the 6th leading cause of death, and there's no cure," Kurilla said.
More than 200,000 of those affected live in Georgia,14,000 of those living in the 17 counties that make up the Augusta region.
Janeabeth Wells' mother is only 69 years old and is already suffering from Early Onset Alzheimer's Disease.
"She does not recognize me as her daughter or her grandchildren so it's pretty difficult. I think the cruelest thing about Alzheimer's is it actually takes the person away from you while they're still physically here," Wells said.
Janeabeth says care taking for her mother is a 24/7 job.
"When she gets up in the morning, it's kind of like having a toddler at home. She does need constant supervision, constant care, we can't leave her alone any longer," Wells explains.
Just last month 80-year-old Effie Lou Parks, who suffers from Alzheimer's, wandered off from her home in Appling. After eight hours of searching, she was finally returned home.
"We just thank God that she's home, and we just urge everybody if you have an Alzheimer's patient or anything, just keep a good eye on them and just protect them as much as you can," her family said.
Her story has a happy ending, but sadly, for most Alzheimer's patients, that's not the case.
With no cure in sight, Janeabeth says coping is about knowledge--understanding the disease-- and love.
"There's no happy ending at all. The only thing you can do is love them," Wells said.
By 2050, the number of people with Alzheimer's in Georgia is expected to triple to as many as 16 million people.
With depressing figures like that, the Alzheimer's Association is trying to spread some hope and knowledge by raising awareness and helping families understand this devastating disease.
They have a pretty high profile event coming up called the Walk to End Alzheimer's and it's on November 3rd.
It's a two to three mile walk that starts at the Augusta Commons.
It helps raise funds and awareness for the disease, but mostly it's about showing the families they're not alone.
Have information or an opinion about this story? Click here to contact the newsroom.
Copyright WRDW-TV News 12. All rights reserved. This material may not be republished without express written permission.
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WASHINGTON (Reuters) - The Supreme Court upheld West Virginia's congressional restricting map as constitutional on Tuesday, overturning a lower court order that found the plan violated the principle of "one person, one vote."
In an unsigned opinion, the court said that a federal district court panel had erred in voiding the map in January and had failed to give appropriate deference to the Democratic-controlled legislature that had crafted it.
West Virginia had argued that it had legitimate interests in allowing small variations in populations served by each district such as making districts compact, not splitting counties between districts, and avoiding contests between incumbents.
The drawing of congressional districts often generates litigation because of its potential to reduce political power of various constituents, including political parties and individual municipalities or counties.
The Jefferson County Commission claimed that West Virginia's plan appeared to dilute the voting power in the state's faster-growing Eastern Panhandle by splitting that region up.
The state's plan also had a population variance between the largest and smallest districts of 0.79 percent of the population of the average district, in line with plans that the Supreme Court had upheld in the past.
But the Supreme Court said it was not essential that a state draw districts with "precise mathematical equality" so long as small variations serve legitimate objectives.
It said such deviations were justified in this case, in light of the state's interests and the absence of better alternatives that offered greater population equality.
The court noted that one alternative, branded by supporters as the "Perfect Plan," would have achieved virtual population equality - a population difference of one person between the largest and smallest districts - at a cost of splitting counties, pitting two incumbents against each other, and moving one-third of the state's population into a new district.
West Virginia has three congressional representatives.
"We're incredibly disappointed," Stephen Skinner, a lawyer for the Jefferson County Commission, said in a telephone interview. "The law until today has been crystal clear, and the Supreme Court has changed the standards. To place arbitrary county lines over mathematical certainty does not comport with truly representative government."
The Supreme Court had put the lower court order on hold while it reviewed the matter. It returned the case to the district court for further proceedings.
The case, brought in the name of West Virginia's secretary of state, is Tennant et al v. Jefferson County Commission, U.S. Supreme Court, No. 11-1184.
(Reporting by Terry Baynes and Jonathan Stempel; Editing by Howard Goller and Doina Chiacu)
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ScienceDaily (Sep. 24, 2012) ? Results of the first-ever clinical drug trial for children with Progeria, a rare, fatal "rapid-aging" disease, demonstrate the efficacy of a farnesyltransferase inhibitor (FTI), a drug originally developed to treat cancer. The clinical trial results, completed only six years after scientists identified the cause of Progeria, included significant improvements in weight gain, bone structure and, most importantly, the cardiovascular system, according to The Progeria Research Foundation (PRF) and Boston Children's Hospital.
The study results were published today in Proceedings of the National Academy of Sciences.
Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS), is a rare, fatal genetic disease characterized by an appearance of accelerated aging in children. All children with Progeria die of the same heart disease that affects millions of normal aging adults (atherosclerosis), but instead of occurring at 60 or 70 years of age, these children may suffer heart attacks and strokes as early as age 5 years, with the average age of death at 13 years.
"To discover that some aspects of damage to the blood vessels in Progeria can not only be slowed by the FTI called lonafarnib, but even partially reversed within just 2.5 years of treatment is a tremendous breakthrough, because cardiovascular disease is the ultimate cause of death in children with Progeria," said Leslie Gordon, MD, PhD, lead author of the study, medical director for PRF, and mother of a child with Progeria. In addition, Dr. Gordon is a staff scientist at Boston Children's Hospital and Harvard Medical School, and associate professor at Hasbro Children's Hospital and Alpert Medical School of Brown University.
Results Yield Improvements in One or More Study Measures for All Children
Twenty-eight children from sixteen countries participated in the two-and-a-half year drug trial, representing 75 percent of known Progeria cases worldwide at the time the trial began. Of those, 26 are children with the classic form of Progeria. The children traveled to Boston every four months to receive comprehensive medical testing through Boston Children's Hospital's Clinical and Translational Study Unit.
Treatment consisted of the FTI lonafarnib, supplied by Merck & Co., given to children orally, twice-a-day over the course of the study, under the supervision of principal investigator Mark Kieran, MD, PhD, director of pediatric medical neuro-oncology at the Dana-Farber/Children's Hospital Cancer Center.
The research team, which included specialists at Boston Children's Hospital, Brigham & Women's Hospital and Dana-Farber Cancer Institute, evaluated the children's rate of weight gain compared to their pre-therapy rate as the primary outcome because children with Progeria experience severe failure to thrive, and have a consistent, very slow linear rate of weight gain over time. Researchers also examined arterial stiffness (a predictor of heart attack and stroke in the general population), bone density and rigidity (indicators of osteoporosis). Every child completing the study showed improvement in an ability to gain additional weight, increased flexibility of blood vessels or improved bone structure.
Results included improvement in one or more of the following areas:
Following the 2003 discovery of the gene that causes Progeria, researchers identified FTIs as a potential drug treatment for Progeria. Children with Progeria have a genetic mutation that leads to the production of the protein progerin, which is responsible for Progeria. Progerin blocks normal cell function and part of its toxic effect on the body is caused by a molecule called a "farnesyl group," which attaches to the progerin protein. FTIs act by blocking the attachment of the farnesyl group onto progerin.
"In the early stages of planning for this clinical trial, we realized that my team's experience using FTIs to treat children with brain cancer could bring together PRF's preclinical research efforts and the expertise we needed to study the drug in children with Progeria," said Kieran, the study's senior author and associate professor of Pediatrics at Harvard Medical School. "The premise behind studying this drug was that by stopping the attachment of the farnesyl group onto progerin in children with Progeria, progerin may be inactivated, reducing some effects of the disease."
"PRF provides a model for disease research organizations, and is a good example of successful translational research, moving from gene discovery to clinical treatment at an unprecedented pace," added Dr. Kieran.
Since PRF's founding in 1999, the organization and its scientific partners have identified the genetic mutation that causes the disease, funded preclinical research and funded clinical trials. A second clinical trial, funded by the National Institutes of Health and PRF, is currently underway and more trials are expected to follow.
"The partnership between The Progeria Research Foundation, the research team and these courageous families was essential for success," said Dr. Gordon. "It required identifying children and their home doctors from around the globe, obtaining the essential pre-trial clinical information, transporting families to and from Boston, supplying translators both inside and outside of the hospital setting, and putting together a multidisciplinary clinical team to assess treatment effects. But it was all worth it, and I believe we have set in motion a blueprint for successful treatment trials for children with Progeria and for other rare diseases."
"The results of this study provide our family with excitement and hope for Megan's future," said Sandy Nighbor, mother of Megan, a 12-year-old child who participated in the clinical trial. "We're grateful to The Progeria Research Foundation and all of the doctors for their commitment to helping my daughter and all children with Progeria."
Progeria Linked to Normal Aging Process
Previous research shows that progerin is also produced in the general population and increases in the body with age. A number of studies successfully linked progerin with normal aging, including a causal link between progerin and genetic instability, specifically telomere dysfunction in the aging process. Researchers plan to continue researching the effect of FTIs, which may help scientists learn more about cardiovascular disease that affects millions, as well as the normal aging process.
"One of the main reasons we achieved breakthrough results in this first trial is because of the tremendous supporters who provided funding, and helped get us one step closer to achieving our ultimate goal -- a cure for Progeria," said Audrey Gordon, Executive Director of PRF. "Every donation makes a difference. With continued support, we will fund research that will not only allow children with Progeria around the world to live long and healthy lives, but may also advance our understanding of the normal aging process that affects us all."
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FILE - In this Sunday, Sept. 23, 2012 file photo, New York Jets trainers attend to cornerback Darrelle Revis (24) during the second half of an NFL football game against the Miami Dolphins, in Miami. Revis has a torn anterior cruciate ligament in his left knee that will require surgery, likely meaning he'll miss the rest of the season, the team announced Monday, Sept. 24. (AP Photo/Rhona Wise, File)
FILE - In this Sunday, Sept. 23, 2012 file photo, New York Jets trainers attend to cornerback Darrelle Revis (24) during the second half of an NFL football game against the Miami Dolphins, in Miami. Revis has a torn anterior cruciate ligament in his left knee that will require surgery, likely meaning he'll miss the rest of the season, the team announced Monday, Sept. 24. (AP Photo/Rhona Wise, File)
FLORHAM PARK, N.J. (AP) ? New York Jets All-Pro cornerback Darrelle Revis has a torn anterior cruciate ligament in his left knee that will require surgery, likely meaning he'll miss the rest of the season.
A somber coach Rex Ryan wouldn't definitively rule Revis out for the season Monday, saying he just found out about the results of the MRI exam. But Revis will have to wait two or three weeks before having surgery, Ryan said, and the recovery from an ACL tear is normally between six and nine months. So, the chances of Revis returning this season appear extremely slim.
Ryan added that he would speak with Revis first before the team decides whether he will be placed on injured reserve.
"It's just disappointing," Ryan said. "This guy wants to win. As great a player as he is individually, he's a great teammate and just wants to win. That's why he was so excited about this year."
Revis was injured in the third quarter of the Jets' 23-20 overtime victory at Miami on Sunday, falling awkwardly and grabbing at his knee even before he hit the grass. It was a non-contact injury, and he wound up covering his face with gloved hands in obvious pain.
He was able to walk off the field, but was taken into the locker room on a golf cart.
Ryan had a feeling the injury was serious when talking to Revis on the plane ride home from Miami on Sunday night, but the team wanted to wait until the MRI results Monday morning confirmed their worst fears.
"Obviously, that's a significant injury," Ryan said. "It's something we have to overcome as a football team. For him, I feel bad about it because he's such a great player and a great teammate. We're going to lose that presence. I don't know what else to say about it.
"I guess that's the horrible thing that came out of the game."
It was Revis' first game back after missing a week with a concussion suffered in the season opener against Buffalo. He had missed only three games before this season, all in 2010.
"Certainly, it's a big disappointment," Ryan said. "I know the way Darrelle is, that this is a guy who's as competitive as it gets, and I don't think there's any doubt that he's going to come back strong from it."
Losing Revis is a huge blow for the Jets, who will now be without their best player and perhaps the NFL's top shutdown cornerback on a defense that Ryan had considered his best since coming to New York. Kyle Wilson, the team's first-round draft pick in 2010, will now step into Revis' starting role opposite Antonio Cromartie.
While Wilson has not lived up to lofty expectations and the drop-off from Revis is huge, the Jets still have two first-rounders starting at the position.
"Most teams have just one No. 1 corner and some teams don't even have any," Ryan said. "We're fortunate that we have the best in the league in Darrelle and a No. 1 corner in Cromartie. We're fortunate there. We drafted Kyle Wilson to basically be a No. 2 corner, and that's what he's going to play, that role, and I'm confident in Kyle."
Ryan also did not rule out looking to sign a free agent to help replace Revis. The Jets released defensive lineman Marcus Dixon on Monday, and Ryan said the move was made in part so the team could pursue other players. Rookie wide receiver Stephen Hill has a hamstring injury that could sideline him a week, so the Jets might need help at that position, too.
Seven of the Jets' current players have had ACL surgeries during their careers, including Cromartie ? who missed his final year at Florida State with a similar injury before being a first-round pick of San Diego in 2006.
Despite losing Revis, Ryan insists he is not panicking about the season.
"It never happens," Ryan said. "We have enough to get it done here. ... We'll find a way to get this done."
The Jets had an ugly, mistake-filled win at Miami, but are in first place in the AFC East at 2-1 ? they hold the tiebreaker over Buffalo ? with tough home games against San Francisco and Houston coming up.
"This is a team game, and as a team, we've got to step it up," Ryan said. "I think we'll respond. We certainly have to accept the challenge, and we're going to come out and compete. We might do it a little differently, but we're certainly going to give it our best shot, without question.
"Is it a major blow when you lose a great player like Darrelle Revis? Of course, it absolutely is. But this is a football team, and I think we showed that yesterday, too."
___
Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL
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Oakland Main Library, 125 14th St, Oakland, CA | Get?Directions??
FREE
Tech Fiction Book Launch
what is Steve doing on The Cloud?
Come find out at the publication party for THE BOOK OF JOBS, a new release from Future Fiction Press.
Author Skye Atman will read from her novel and take you on a virtual tour of The Cloud.
NOTE TO APPLE FANS: you'll learn how Steve Jobs continues to 'Think Different', takes on the Big Guy, challenges The Cloud World Order, meets a talented goddess named Siri, and gets the answers to his questions about death?and life.
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Delicious goodies donated by Sweet Adeline Bakeshop
Free McIntosh for all (the apple!)
Books available for purchase and signing
Excerpts, Cast of Characters, Advance Reviews at?www.skyeatman.com
Serial Blog about Steve's daily life at?http://www.book-of-jobs.com
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37.80129
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primary
October 6, 2012, 3:00 pm?5:00 pm
Oakland Main Library
125 14th St, Oakland, CA
Bradley Walters Community Room
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Source: http://albany.patch.com/events/tech-fiction-book-launch
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Source: http://cons-sheratan.blogspot.com/2012/09/tech-fiction-book-launch-albany-art.html
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When President Obama on Wednesday expressed the hope that "30 years from now, we will have seen further evolution" in China's respect for human rights, I thought about Geng He, who had come to visit me the day before.
Geng He, 43, is a soft-spoken woman who doesn't know whether her husband, Gao Zhisheng, is dead or alive. She knows that over the past five years, he has been repeatedly tortured by Chinese security agents. She knows that he was last seen nine months ago, when some of those agents spirited him away. She's pretty sure that he has not been charged with a crime, but the government will not say where he is.
Gao is not a dissident. He is something China's government apparently finds even more threatening: a lawyer who has sought, while adhering scrupulously to Chinese law, to represent dissidents, members of religious minorities and other victims of Communist Party repression.
"For him, being a lawyer is more than just a profession," Geng told me. "He's tried to educate the public about justice, about the law, and about what's right or wrong. Now, there seems to be no room for someone like that to survive in China."
Geng had hoped that Obama would speak out about her husband's case, both because such attention might help him and because Obama's words could have a big impact more broadly in China. As she wrote in a Post op-ed last year:
"I worry about the next generation of Chinese lawyers. Will disappearances like my husband's deter them from becoming rights defenders? I imagine so. But if the United States were to speak out on my husband's behalf, perhaps this would change."
And also:
"My 8-year-old son, Peter, was surprised to discover last week that President Obama is a lawyer. To him, lawyers are people the government throws into prison, not leaders of the government itself. He asked me whether this meant that President Obama could help free his father. I told him that I hoped so. We are waiting to see."
Obama said in a prepared statement, leading off a White House news conference with Chinese President Hu Jintao, that the two leaders had discussed human rights in their private meeting. I hope those discussions will help Gao as well as other individuals Obama chose not to mention publicly, such as imprisoned Nobel Peace Prize laureate Liu Xiaobo and his wife, Liu Xia, who is under de facto house arrest. When I asked whether Obama had raised Gao's case with China's president, a White House spokesman e-mailed me that "the President referred to the list of names he had raised in the past that included Gao."
What may have a bigger impact is Obama's apparent acceptance, in his off-the-cuff answers, of China's own rationalizations for repression: that "China's at a different stage of development than we are"; that "part of human rights is people being able to make a living and having enough to eat"; and, most of all, that "there has been an evolution in China over the last 30 years. . . . And my expectation is that 30 years from now we will have seen further evolution and further change."
What's alarming is not just that 30 years is a long time to ask Gao's two children to wait. It's the assumption that China is moving, perhaps too slowly but inexorably, in the right direction, because that's how nations evolve as they become more prosperous. The statement uncannily echoes Bush administration comments about Russia over the past decade, as President (now Prime Minister) Vladimir Putin chipped away at freedom there.
Of course, the Bush officials were right that Russia remained freer than it was in the days of the gulag, and Obama is right that China is freer today than in the lunatic days of the Cultural Revolution. But as Freedom House documented in a report last week, the world has become, on balance, less free over the past decade, with China and Russia leading the retrenchment. In China, as the most recent State Department annual report noted, "The government's human rights record remained poor and worsened in some areas."
Since Hu became Communist Party secretary in 2002, in fact, repression has intensified steadily - against Internet freedom, democracy activists, religious liberty, Tibetans and other ethnic minorities, and, perhaps most notably, against lawyers such as Gao who tried to work within the system. Much like Russia in its neighborhood, China also has flexed its muscles to protect autocracies and stymie democracy from advancing in smaller nearby countries such as Burma and Cambodia.
The question is whether the United States and other democracies will acknowledge the dictators' successful push back and seek strategies to counter it. Such strategies would be difficult. They would demand trade-offs against other goals. They might fail.
The alternative - to assume that in 30 years things will be better - comfortably absolves the United States of having to do anything. That removes any risk of failure - but also any chance of helping to steer things Gao's way.
fredhiatt@washpost.com
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LONG XUYEN, Vietnam (AP) ? Vu Dinh Son was 18 months old when his father left home to fight American forces in Vietnam, and just 2 when the man was killed in a foxhole encounter with U.S. Marines. But the son now has fresh glimpses into the life of the father he never knew thanks to a wartime diary, returned to him courtesy of the United States.
The pocket-sized book was brought to Vietnam in June by Defense Secretary Leon Panetta, who, in return, was handed a bundle of letters written by an American soldier that had been kept in Vietnam. The high-level exchange of artifacts symbolized a joint desire for closer ties by the former enemies, who now share concerns over China's rise.
U.S. Marine Robert "Ira" Frazure took the diary from the chest of Son's father, Vu Dinh Doan, in March 1966 and then took it home with him, presumably as a war souvenir. Earlier this year, he asked the sister of a fellow Vietnam vet to track down Doan's family in Vietnam to return the diary. She did that with the help of the PBS television program "History Detectives," which tracked down Doan's family earlier this year.
"When my father left for the battlefield, I was too small to know anything, I was not even able to call out 'Dad,'" Son said Friday after a tearful ceremony outside his house during which the diary was returned, along with a photo of him and two bank notes.
"Whatever he wrote in his small diary will make us extremely happy," Son said. "We are tremendously proud of him, and in our heart he is a tremendous hero."
The red book is hard to decipher in places, but gives a flavor of the life of a North Vietnamese soldier at the beginning of the war: Entries talk of a 15-day march by Doan, hunger staved off with a meal of rice, salt and shrimp paste, and a vow to destroy "eight planes and five tanks."
The artifacts were placed during the ceremony next to a photo of Doan, whose body was recovered four years ago, in his uniform in front of burning incense. Above him was a photo of revolutionary leader Ho Chi Minh. Afterward, the family went to pray at his grave, which is in a cemetery reserved for war dead a short drive from the family house.
The United States and Vietnam normalized relations in 1995, 20 years after the end of a war that resulted in the deaths of an estimated 3 million Vietnamese and 54,000 U.S. soldiers. They have largely agreed to move on from the war, though tensions remain over effects of dioxide sprayed by the United States and Vietnam's human rights record. The U.S. relies on Vietnamese cooperation in its hunt for the remains of American soldiers in the country. The two countries have exchanged artifacts before, but never at such a high level. Rarely, if ever, has the Vietnamese army invited the media to cover the events.
The United States is seeking to boost its military and economic ties with Vietnam and other Southeast Asian nations, in a so-called "Asian Pivot" to contain China's influence in the region. Many of the countries, including Vietnam, share U.S. concerns regarding China and are looking toward Washington for diplomatic and military support.
Friday's ceremony, which took place a short drive east of Vietnam's capital, Hanoi, was attended by a representative of the U.S. military, but was organized by Vietnam. Its army is keen to show that it is trying to track down the possessions of dead soldiers, not to mention their bodies. There are still some 300,000 Vietnamese soldiers whose remains have yet to be found.
"This is a chance to remind the country of its tradition of fighting foreign aggressors and liberating the country," Col. Nguyen Xuan Nang said after the ceremony. "It reflects warming relations between the U.S. and Vietnam."
Source: http://news.yahoo.com/returned-vietnam-diary-gives-son-glimpse-father-050403170.html
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